Jan 24, 2025 · Summary Untangling the effects of elevated Aβ from those due to APP overexpression is a common challenge when interpreting the phenotypes of APP transgenic …

Jan 30, 2025 · Summary APPPS1 mice contain human transgenes for both APP bearing the Swedish mutation and PSEN1 containing an L166P mutation, both under the control of the …

Aug 13, 2019 · In App NL-G-F /MAPT double knock-in mice, the expression of the App and MAPT genes is under the control of natural regulatory elements, mice express normal levels of APP …

Oct 8, 2019 · These transgenic mice were made by co-injecting two vectors encoding mutant APP and mutant PSEN1, respectively. Like the APPSwe/PSEN1dE9 mice generated by crossing …

Jan 18, 2015 · 5xFAD mice express human APP and PSEN1 transgenes with a total of five AD-linked mutations: the Swedish (K670N/M671L), Florida (I716V), and London (V717I) mutations …

Oct 7, 2019 · APPswe/PSEN1dE9 mice carry two transgenes with AD-linked mutations: a chimeric mouse/human APP with the Swedish mutation and human PSEN1 lacking exon 9 …

May 21, 2002 · APP23 is a transgenic mouse model used to study Alzheimer's disease, expressing human amyloid precursor protein with the Swedish mutation.

Dec 16, 2020 · The App SAA mouse joins a list of knock-in models that carry a humanized Aβ sequence within the murine App gene (App knock-in (humanized Aβ), APP NL-F Knock-in, …

Jan 30, 2025 · Single-cell embryos from mice with knock-in of PSEN1 with the PS1M146V mutation were injected with two human transgenes (APP with the Swedish mutation and …

There is a large, ongoing effort to characterize disease models in order to better understand pathophysiology as well as to identify models suitable for investigating potential therapeutics. …