Nov 17, 2025 · Unlike calculated log P, which describes lipophilicity for neutral compounds only, the calculated distribution coefficient, log D, changes with pH as its calculations account for all forms of a …

For non-ionizable compounds LogP = LogD throughout pH range, whereas for ionizable compounds LogD takes into account the partition of both ionized and non-ionized forms.

Jan 6, 2024 · There is a nice theoretical relationship between LogD, LogP and pKa. The method, known as CALlogD, can be derived from the predicted LogP and pKa values (Wang et al. 2023).

May 15, 2017 · For non-ionizable compounds Log P = Log D throughout pH range, whereas for ionizable compounds Log D takes into account the partition of both ionized and non-ionized forms.

Ibuprofen has the typical log D vs. pH profile that is characteristic of acidic compounds. Lipophilic behavior of ibuprofen will be dominant when its carboxylic group is unionized (at low pH).

Ibuprofen has the typical log D vs. pH profile that is characteristic of acidic compounds. Lipophilic behavior of ibuprofen will be dominant when its carboxylic group is unionized (at low pH).

Jan 12, 2019 · LogP is a component of Lipinski’s Rule of 5 a rule of thumb to predict solubility and permeability that has become a surrogate for drug-likeness.

Jan 12, 2025 · Two key physicochemical properties that play a pivotal role in determining a compound’s pharmacokinetic and pharmacodynamic profile are LogP and LogD. These parameters, reflecting...

While logP and logD both describe the same physical property (lipophilicity) it is critical that we understand the differences between them and apply them accordingly.

When it comes to logP vs. logD, the difference is in pH dependency. Whereas logP is pH independent, logD changes depending on pH levels. The partition coefficient LogP is a constant for the molecule in …